Medicinal Chemistry

ISSN: 2161-0444

Open Access

Synthesis, FTIR and Electronic Spectra Studies of Metal (II) Complexes of Pyrazine-2-Carboxylic Acid Derivative


Nzikayel S, Akpan IJ and Adams EC

Aminolysis of pyrazine-2-carboxylic acid was carried out through an intermediate ethyl pyrazinoate formed by a reaction between pyrazine-2-carboxylic acid and ethanol in the presence of concentrated sulfuric acid under reflux which was then reacted with 2-Aminopyridine under same reflux and the final product proposed theoretically N-(pyridin- 2-yl)pyrazine-2-carboxamide a novel compound was characterized using FTIR spectroscopy, UV/Visible spectroscopy and other physical measurement such as melting point determination, solubility were determined. The FT-IR spectrum of the proposed compound showed absorption shift different from the starting ligand(POA) having (NH) stretch at 3323 cm-1 and (3349 cm-1, 3256 cm-1) of A1 and A2 ligands respectively, (CO) stretch at 1665 cm-1 and 1678 cm-1 for PYPC1 and PYPC2 respectively. The complexes A3 and A5 spectra studies showed a Cu-N, Cu-O, Co-N, and Co-O coordination.


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