Lyvia do Prado Pacheco*, Amanda Borges, Gabriela Heringer, Lícia Gobeti, Luciene Lage da Motta and Antônio Chambô Filho
Background: Primary fallopian tube cancer is a rare and highly malignant neoplasm, frequently confused with ovarian cancer. Among the risk factors, mutations in the BRCA-1 and BRCA-2 genes play an important role. The gold standard for diagnosis is postoperative histological examination. Treatment is based on surgery, and patients with BRCA-½ mutations are indicated for screening and preventive rehabilitation due to the high risk of tumor of the fallopian tube. This article aims to report the case of a 58-year-old patient with a condition of a solid serous carcinoma of the fallopian tube.
Methods: The information was obtained through analysis and review from the patient's medical record, photographic records of the lesions, and literature review.
Results: It is demonstrated that a significant number of serous carcinomas pelvic are originated in the fallopian tubes, especially in patients carrying mutations in the BRCA1 genes and BRCA2. In this reported case, the absence of ovarian abnormalities and the isolated involvement of the fallopian tube support this interpretation; moreover, the presence of a BRCA1 mutation reinforces the increased risk and the need for risk-reducing salpingo-oophorectomy. Even in the early stages, it is noticeable that high-grade serous neoplasms present a high risk of recurrence, and adjuvant chemotherapy is indicated based on staging, tumor grade, and genetic profile.
Conclusion: The reported case reinforces the importance of evaluating and considering the fallopian tube as a site of origin for serous carcinomas, particularly in patients with BRCA1 or BRCA2 mutations. The association between genetic factors and the tumor’s morphological characteristics highlights the relevance of follow-up and individualized prevention strategies in these patients.
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