Oral Health Case Reports

ISSN: 2471-8726

Open Access

Oral Inflammatory Myofibroblastic Tumor: Two Additional Cases and Literature Review


Nagamani Narayana, Hardeep Chehal

OIMT poses a diagnostic challenge as it is part of the vast spectrum of spindle cell neoplasms. It is a controversial tumor composed of a proliferation of myofibroblasts intermingled with an inflammatory cell infiltrate composed of lymphocytes, plasma cells, and eosinophils in focal areas of collagenous stroma. Before this nomenclature was proposed by World Health Organization (WHO) in 1994, this entity was defined by a variety of names such as: inflammatory pseudotumor, histiocytoma, plasma cell histiocytoma complex, plasma cell granuloma, fibrohistiocytoma, xanthomatous granuloma, myxoid hamartoma, xanthomatous pseudotumor, spindle cell pseudotumor, inflammatory fibrosarcoma, benign myofibroblastoma, and inflammatory myofibroblastic proliferation. WHO has classified OIMT as an intermediate soft-tissue myofibroblastic neoplasm according to its well reproducible histological morphology. The first case was reported in the lungs and though it may be found anywhere in the body, the lung, liver and gastrointestinal tract are the most common sites of involvement. In the head and neck region, it has been reported in the orbit, larynx, parapharyngeal spaces, maxillary sinus, submandibular region and the oral cavity. Oral lesions may be intraosseous or in the soft tissue. The etiology is controversial


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