Journal of Surgery

ISSN: [Jurnalul de chirurgie]
ISSN: 1584-9341

Open Access

Obesity is Linked with Inflammation-Evaluation of Subclinical Inflammatory Status in Obese Patients


Roxana Maria Livadariu, Daniel Timofte, Radu Dănilă, Ana Maria Sîngeap, Daniela Constantinescu, Anca Trifan

Background: Obesity is one of the most important public health; it seems that inflammation is a pathogenic pathway between obesity and its associated comorbidities. The aim of the study was to evaluate the status of serum inflammatory markers in a group of obese patients hospitalized for bariatric surgery.
Materials and methods: We performed a retrospective study on 64 obese patients successively hospitalised in our Surgical Unit between November 2014 and November 2016. All patients received a full evaluation including medical and personal history, complete clinical examination, and anthropometric measurements as well as general and special biological tests. The inflammatory status of each patient was evaluated by serum values of fibrinogen, CRP, Leptin and NLR and PLR scores. Insulin resistance was assesed by the homeostasis model assessment of insulin resistance index. We noted the presence of metabolic syndrome and its components and also the presence of obstructive sleep apnea syndrome.
Results: 62.5% of patients had ≤45 years and the number of male patients was significantly lower (23.4%) than the number of females. The mean value of BMI was 45.06 ± 6.67 SD and the mean value of waist circumference was 133.39 cm ± 17.47 SD. The mean values of serum inflammatory markers (fibrinogen, CRP and leptin) were abnormally elevated. There was a directly proportional relationship between the increasing of waist circumference and serum fibrinogen (p=0.04) and CRP (p=0.003) variation. Elevated fibrinogen values corelated with MS, DM II and OSA. Increased leptin values corelated with BMI, HOMA IR and OSA.
Conclusion: Elevated serum values of fibrinogen and CRP correlate especially with abdominal obesity, quantified by waist circumference, while increased pathological values of serum leptin correlates also with BMI. Of all inflammatory markers assesed in the study, elevated fibrinogen appear to be most sensitively related to the presence of MS, OSA and DM II.


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