Among the new therapeutic approaches based on medicinal plants and their extracts, the application of essential oils is getting more and more attention. The spread of drug-resistant clinical isolates has increased as a result of the widespread use of synthetic and semi-synthetic antimicrobials. As a result, natural products like essential oils are being studied as potential antimicrobial resources. We compared the effects of common antimicrobials and essential oils on the microbicidal activity of human phagocytes in the context of a potential infection. These essential oils show antifungal drug-like. The data from the literature on the interactions between essential oils and the immune system are compared to our findings. This comparison would help fill in any remaining knowledge gaps regarding the bioactivity of essential oils and assist in the identification of therapeutic solutions to the antibiotic resistance that is becoming increasingly prevalent. There has been a significant rise in clinical interest in natural medicine over the past thirty years, with a focus on the widespread use of plant products in microbiology. The emergence of newer diseases and the rise in microorganism resistance to antimicrobials necessitate the urgent development of new, more potent medications.
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