Journal of Nursing & Care

ISSN: 2167-1168

Open Access

Glucono-Delta-Lactone: An In Vitro Inhibitor of Hyperglycemia-Induced Coagulation


Charles R Spillert, Irene N Ojini

Diabetes is a disease in which premature development of conditions which increase blood coagulation are the leading cause of death. A reduction in the consequences of elevated glucose levels is the main focus of clinical treatment. It has been determined that the addition of glucose to anti-coagulated human blood, followed by incubation for 24 hours results in the generation of a hypercoagulable state, which is evaluated by reduction in whole blood clotting time. Incubation for 2 hours did not show the same change in clotting. Furthermore, the addition of glucono-delta-lactone, a low-toxicity food additive mitigated the hypercoagulable state which may, in part, be produced by tissue factor generated by up-regulated monocytes. This demonstration of in vitro glucose toxicity may broaden our clinical knowledge of the diabetic state. Also, glucono-delta-lactone warrants additional studies to confirm its anticoagulant properties.


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Copyright: This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Received Date: Jan 01, 1970
Accepted Date: Jan 01, 1970
Published Date: Jan 01, 1970

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