Chemical Sciences Journal

Functionalization of Ibuprofen Core Structure Compound:Synthesis of New Potential Chemotherapeutic Agents Incorporating Ibuprofen Substructure

Abstract

Shaaban K Mohamed1, Mustafa R Albayati, Sabry HH Younes, Mohammed G Abed-Alkareem

New series of potential biologically active agents have been synthesized by functionalization of ibuprofen core structure involving hydrazidic, heterocyclic, quinone and indole containing motifs. The targeted products have been achieved in a very good yield (average 75%) under conventional heat and irradiation conditions. All compounds have been characterized by IR, 1H-NMR, 13C-NMR and Mass spectra.