Elaheh Jafari and Hojjatallah Alaei
In this research, the effect of hippocampal electrical stimulation on brain waves and spatial memory was studied. The rats were anaesthetized and the electrodes were implanted into the CA1 by stereotaxic instrument. Electrical stimulation with (25 μA) and (100 μA) were induced into CA1; then spatial learning and memory was investigated by Morris water maze test, and then EEG was recorded for each rat. Learning increased in the group stimulated with 25 μA frequency compared to the sham group (P<0.05). This effect increased with high intensity (100 μA) of electrical stimulation. (One-way ANOVA, Tukey's; P=0.041). Also, this current intensity electrical stimulation increases frequency waves of delta (53.88 ± 2.03), reducing the frequency waves of alpha (11.96 ± 0.68), beta (19.72 ± 1.03), and theta (14.42 ± 0.85).
Therefore, electrical stimulation strengthened and improved the recall stage (Tukey's: P=0.007). As well as, high-intensity electrical simulation visible impact on brain waves are delta waves, which play important role to consolidation of memory.
PDFShare this article
Epilepsy Journal received 41 citations as per Google Scholar report
