Ahmed ASM, Arbab NMH,Ibrahim YEY
Background: Delta virus or hepatitis D virus (HDV) is a small RNA-containing virus requiring the concomitant presence of hepatitis B virus (HBV) for its survival and pathogenicity. Within a few years of its discovery, it was linked to cases of progressive chronic hepatitis B. Approximately, 5% of the patients with chronic hepatitis B infection worldwide are infected with HDV. Development of chronic kidney disease (CKD) has become a serious problem worldwide. CKD is characterized by a slow and progressive decline in the kidney function. Some of the manifestations of CKD include atherosclerosis, increased hemolysis, platelet dysfunction, and neuropathy. Carriers of HBV are at increased risk of developing cirrhosis, hepatic decompensation, and hepatocellular carcinoma. This study aimed to assess the prevalence of HDV among HBV on hemodialysis and correlating its relationship with age, gender.
Materials and methods: This was an active surveillance cross sectional study conducted to detect the prevalence of HDV among HBV on hemodialysis. Ninety (90) HBV on hemodialysis patients were recruited in this study. It conducted at AL-shaheda Salma center for hemodialysis and hemodialysis center of Unmada hospital in Khartoum, Sudan from April to June 2017. All statistical analyses were performed by SPSS software version (20). Continuous variables were expressed as mean and standard deviation. Comparison between groups was performed with Pearson correlation. P-value<0.05 was considered significant.
Results: In this study, increase prevalence of HDV among hepatitis B patients on hemodialysis was the most important findings. 13.3% of cases showed positive HDV, 61% of participants were males with mean age 44.8 ± 8. HDV had positive correlation with age when (R=0.249, P=0.018).
Conclusion: This study ensures that; increase possibility of HDV infection among hepatitis B patients on hemodialysis.
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Journal of Microbiology and Pathology received 18 citations as per Google Scholar report
