Journal of Pharmacognosy & Natural Products

ISSN: 2472-0992

Open Access

Anti-dormant Mycobacterium bovis Produced by Indonesian’s Marine Sponge Xestospongia muta


Guntur Febrian Illahi, Rauzatul Sakinah, Nanda Muhammad Razi, Syarifah Keumala, Khairunnisa and Viqqi Kurnianda

Mycobacterium bovis is the causative agent for tuberculosis disease. This Mycobacterium has an ability to become dormant. Isolation and characterization of bioactive compounds from Indonesian’s Marine Sponge Xestospongia muta, Clathria sp., and Endectyon delaubenfelsi have been done on May 2018. Bioactive compound was isolated based on bioassay-guided separation. The results of Minimum Inhibitory Concentration showed cytotoxic from Xestospongia muta is 0.4 μg/mL, Clathria sp. is 0.5 μg/mL, and Endectyon delaubenfelsi is 0.8 μg/mL. Interpretation of FTIR spectrum showed that the active compound from Xestospongia muta has O-H alcohol functional group at 3435 to 56 cm-1 with the fingerprint region of C-O alcohol functional group at 1342 to 24 cm-1. The C≡N imine functional group was detected at 2365 to 28 cm-1 with fingerprint region of C-N imine at 1637 to 27 cm-1 indicate that the active compound as alkaloid. Based on MIC50 indicate that MIC50 from Xestospongia muta has the highest activity against Mycobacterium bovis.


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