The plants are rich in anti-microbial agents for their anti-microbial activity. In this study, the powdered leaves extracts of Ixora coccinea and Datura metel were macerated and extracted with solvents in acetone, methanol and iso-propanol. The study was done to evaluate the anti-microbial property of leaf extracts of Ixora coccinea and Datura metel against the bacterial strain of Escherichia coli and Staphylococcus aureus by agar well diffusion method. From the antimicrobial activity assay, the best zone of inhibition formation li whereas Datura metel had shown good anti-bacterial activity against Staph of 11.8 ± 0.64 mm was observed in the case of Ixora coccinea against the bacterial strain of Escherichia coli Staphylococcus aureus by the inhibition zone formation of 15.3 ± 0.27 mm.

Ezrin Peptide Therapy was invented in London and developed in Moscow over the previous three decades. Synthetic 14 amino acid peptides that mimic a receptor site in human ezrin, inhibit inflammation and amplify adaptive anti-viral immunity. Human Ezrin Peptide One (HEP1, Gepon) was registered for human use in the Russian Federation in 2001. The successful treatment with ezrin peptides of acute viral respiratory infection with pneumonia complications, led to testing of ezrin peptides as a potential COVID therapy. RepG3, a derivative peptide of HEP1, which has double the IL-6-expression inhibition activity, is being developed as a therapy for COVID and may also help to prevent SARS-CoV-2 re-infection.