Therapeutic potential for COPD treatment, evidence for stem cell and natural product therapy

3^rd International Conference on Chronic Obstructive Pulmonary Disease

July 11-12, 2016 Brisbane, Australia

Mohammad Hossein Boskabady, Leila Gholami Mahtaj, Azadeh Feizpour, Ahmad Ghorbani and Rana Keyhanmanesh

Mashhad University of Medical Sciences, Iran
Tabriz University of Medical Sciences, Iran

Posters & Accepted Abstracts: J Pulm Respir Med

Abstract :

In a series of studies various possible therapeutic potential of natural product and stem cell for treatment of COPD were examined. Th e eff ect of adipose derived stromal cells (ASCs) on tracheal responsiveness, interleukin-8 (IL-8), total and diff erential white blood cells (WBC) counts in animal model of COPD was shown. Th e eff ect of ASCs on lung histopathologic changes and serum level of malondialdehyde (MDA) in COPD animals was also demonstrated in another study. Th e eff ect of Zataria multifl ora and its constituent, carvacrol on systemic infl ammation including serum levels of IL-8 and MDA as well as total and diff erential white blood cell (WBC) in the blood of guinea pig COPD model was documented in two studies. Th e preventive eff ect of Zataria multifl ora and carvacrol on thiol groups, IL-8, total and diff erential WBC broncho-alveolar lavage fl uid (BALF), lung pathology and tracheal responsiveness, were also demonstrated. Tracheal responsiveness to both methacholine and ovalbumin reduced in COPD animal model due to Nigella sativa extract and vitamin C treatment. Th e preventive eff ect of vitamine E, dexamethazone and the extract of Nigella sativa on tracheal responsiveness and lung infl ammation of sulfur mustard exposed animals was studied. Signifi cant improvement in pulmonary function tests and respiratory symptoms in chemical war victims treated with the extract of Nigella sativa for two month was also observed. Th e results of these studies indicated a promising therapeutic potential for stem cell and natural product in the treatment of COPD which should be clinically evaluated in further studies.

Biography :

Email: BoskabadyMH@mums.ac.ir