Hubei Maternity and Child Health Hospital, China
Posters & Accepted Abstracts: J Cancer Sci Ther
Objective: To investigate the prognostic effect of the tumor-infiltrating neutrophils in cervical cancer, and the effect of bone marrow neutrophils on the growth and angiogenesis of U14 mice cervical cancer cell lines. Method: International Federation of Gynecology and Obstetrics (FIGO) stage I B and II A treatment-naive cervical cancer patients (N=46) were assessed for tumor-infiltrating CD66b+ neutrophils by immunohistochemistry. Results were correlated with recurrence-free survival (RFS) as end point. Bone marrow neutrophils separated form naive and tumor-bearing mouse were used to co-inoculate with the U14 mice cervical cancer cell line to observe the effect of neutrophils on the growth and angiogenesis of U14 cell line. Result: The group with a density of CD66b+ neutrophils above median in the tissue of cervical cancer was associated with shorter RFS than the group with a density of CD66b+ neutrophils below median, and the 2 groups had a statistic difference (P=0.021). The bone marrow neutrophils from the tumor-bearing mouse had the ability to promote tumor growth and angiogenesis of U14 cervical cancer cell line. Conclusion: The increasing number of the tumor-infiltrating neutrophils in cervical cancer tissues was correlated with the short recurrence free survival of the patients of cervical cancer, and the tumor environment could change the neutrophils to act in a way that favors tumor angiogenesis and tumor growth.
Cancer Science & Therapy received 3644 citations as per Google Scholar report