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Synthesis and characterization of modified starch hydrogels for photodynamic treatment of cancer
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Cancer Science & Therapy

ISSN: 1948-5956

Open Access

Synthesis and characterization of modified starch hydrogels for photodynamic treatment of cancer


3rd World Congress on Cancer Science & Therapy

October 21-23, 2013 DoubleTree by Hilton Hotel San Francisco Airport, CA, USA

Mohammad Reza Saboktakin

Accepted Abstracts: J Cancer Sci Ther

Abstract :

The objective of the present study was to develop carboxymethyl starch (CMS) and dextran sulfate (DS) hydrogels that are able to efficiently encapsulate 5, 10, 15, 20-tetrakis ( meso -hydroxyphenyl) porphyrin (mTHPP), a porphyrin-based PS agent. The study showed that the lifetime of the triplet state for porphyrin PS is significantly increase when encapsulate into hydrogel. In addition to the possible enhancement of 1O2 generation, other advantages to incorporating porphyrin-based PS agents into hydrogel include the ability to solubilize these generally hydrophobic agents, the small and uniform size of hydrogels, and potential for passive targeting of solid tumors via the enhanced permeation and retention effect decreasing systemic photosensitization. This novel type of carboxymethyl starch (CMS) hydrogel using dextran sulfate (DS) as a polyanionic polymer was developed to achieve complex coacervation for the incorporation and controlled release of an anti-angiogenesis hexapeptide, this was the first report describing the use of DS to formulate CMS based hydrogels. Keywords: Modified starch, Dextran sulfate, Hydrogels, Photodynamic therapy, Cancer.

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