Tanushree Singha, Jagadish Singh and T. K. Maity
Accepted Abstracts: J Cancer Sci Ther
Aseries of 2, 5-disubstituted 1, 3, 4-oxadiazole derivatives (4A-4G) have been synthesized starting from aromatic benzaldehyde. All the synthesized compounds contain toxophoric -N=C-O- linkage in oxadiazole ring. This 1, 3, 4-oxadiazole heterocyclics are very good bioisosteres of amide and ester. The structures of the final compounds were characterized by using IR, 1HNMR and mass spectroscopy. The anticancer study was investigated against Ehrlich ascites carcinoma bearing albino mice. The synthesized (4A-4G) compounds were administered intraperitoneally at dose of 20-25 mg/kg; body weight per day for 7 days after 24 hour of tumor inoculation in mice. 5-Fluorouracil (20mg/kg; body weight) was used as the standard drug. Synthesized compounds (4A-4G) treated group remarkably decrease the body weight, tumor volume, packed cell volume, viable cell count and increase the tumor weight (%) inhibition, tumor cells (%) inhibition, the life span, and nonviable cell count of EAC tumor bearing mice when compared with the control group. Synthesized compounds (4A-4G) also showed significant results on different hematological parameters of cancer. All the synthesized compounds (4A-4G) revealed significant anticancer activity in EAC bearing mice. The present investigation supported those derivatives of oxadiazole as potent anticancer molecules for future study.
Tanushree Singha has completed her post graduation i.e., M. Pharma at the age of 26 years from Jadavpur University. Presently she is a research fellow in Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India. She has published 3 papers in reputed journals and 2 papers are also communicated in reputed journal.