Spectroscopic investigation of 4-Aminoantipyrine napthoyl derivative – An AL3+ sensor: Photo physical, molecular docking and anticancer cytotoxicity studies

14^th World Cancer & Anti-Cancer Therapy Convention

November 21-23, 2016 Dubai, UAE

D Premnath, S Kumaresan, G Tamil Selvan, Israel V M V Enoch, P Mosae Selvakumar and M Indiraleka

Karunya University, India
Mepco Schlenk Engineering College, India

Posters & Accepted Abstracts: J Cancer Sci Ther

Abstract :

Substituted aromatic carbonyl compound of 4-Aminoantipyrine N-(1,5-Dimethyl-3-oxo-2-phenyl-2, 3-dihydro-1H-pyrazol-4- yl)-2, 3, 4, 5, 6-pentafluoro-benzamide was synthesized by the condensation of naphthoyl chloride and 4-Aminoantipyrine.The compound was characterized using IR, Mass, 1H, 13C NMR, UV-Visible and fluorescence spectroscopy. The compounds show dual fluorescence, with broad emission bands at 340 nm and 450 nm. In the presence of Al3+, the compound shows a fluorescence enhancement, while the other metal ions do not show significant change of fluorescence in aqueous solution. The 4-Aminoantipyrine derivative binds to Al3+ metal ion with a 1:1 stoichiometry. Molecular docking is done with HPV16-E7 target protein receptor by using Glide protocol in order to understand the theoretically plausible drugâ��receptor recognition. The derivatives were screened in vitro cytotoxic activity with reference drug Pazopanib respectively against human cervical cancer cell line (SiHa) by MTT assay method. The bioactivity of these derivatives has also been evaluated with respect Glide docking interaction using Schr�¶dinger software. Compound shows a potential activity (IC50=0.9274 �¼M) which is similar to the standard drug Pazopanib.

Biography :

Email: prems.bioinfo@gmail.com