Prognostic implications of hyaluronic acid binding protein 1 (HABP1) expression; estrogen receptor (ER) and progesterone receptor (PR) loss in endometrial carcinoma

16^th Global Annual Oncologists Meeting

April 24-25, 2017 Dubai, UAE

Ola A Harb, Mariem A Elfeky, Safa A Balata, Ola M Elfarargy, Rham Z Ahmed, Amr Abd Almohsen Alnemr and Loay M Gertallah

Zagazig University, Egypt

Posters & Accepted Abstracts: J Cancer Sci Ther

Abstract :

Background: Novel prognostic and predictive markers for endometrial carcinoma (EC) were needed for better management of patients. Hyaluronic acid binding protein 1 (HABP1), was primarily discovered in cervical carcinoma (HeLa) cells, and its prognostic importance in EC is still not sufficiently clarified. ER & PR hormone receptors are biological molecules that have been studied as prognostic markers because of their essential physiological rules. Aim: The aim of this study was to explore the expressions of HABP1, ER & PR in EC patients, correlating their expressions with clinico-pathological factors and prognosis of the patients. Methods: HABP1, ER & PR expressions were evaluated in sections from 60 paraffin blocks of EC. We analyzed correlations between the levels of markers expressions and prognosis of our patients. Results: High expression of HABP1was significantly positively correlated with grade, stage of the tumor (p<0.001 for all) and presence of distant metastases (p=0.009). Loss of ER & PR hormonal expression was significantly positively correlated with presence of L N metastases and presence of distant metastases (p<0.001 for all). Cases with ER & PR hormonal receptors loss and high expression of HABP1 showed poor response to therapy, increase in incidence of tumor recurrence and shortened 5 year disease free survival and 5 year overall survival (p<0.001 for all). Conclusion: HABP1 high expression with loss of ER & PR hormonal receptors are markers of poor prognosis for EC patients.

Biography :

Email: olaharb2015@gmail.com