Preclinical testing of naturally-sourced bioactive compounds for protection against chemotherapyinduced mucositis

4^th World Congress on Cancer Science & Therapy

October 20-22, 2014 DoubleTree by Hilton Hotel Chicago-North Shore Conference Center, USA

Gordon S Howarth

Accepted Abstracts: J Cancer Sci Ther

Abstract :

This lecture will address a variety of topics related to the use of rodent models for pre-clinical development of candidate naturally-sourced bioactive compounds (nutraceuticals) to protect the alimentary tract against chemotherapy-induced intestinal mucositis. It will include discussion of: strategies underlying the selection of animal models for studies of mucositis; the development of plant-sourced bioactives (including grape seed extracts); the development of animal-sourced compounds (including whey-derived products and Emu Oil); the development of new probiotics and prebiotics; novel combination therapies and also the application of new non-invasive breath-testing techniques to monitor the impact of chemotherapy and the subsequent effects of the new bioactive agents on a range of gastrointestinal functions. In addition to these subjects, attendees of this lecture will be familiarized with the need for rigorous and stringent testing of candidate therapeutics, so that only the most promising therapies are advanced to clinical trial evaluation of efficacy in cancer patients undergoing chemotherapy.

Biography :

Gordon S Howarth has studied chemotherapy-induced mucositis and new therapeutic approaches for 20+ years, during which time he has authored more than 130 peer-reviewed research papers and review articles. He serves on the editorial boards for the Journal of Nutrition and Inflammation & Allergy. He is currently the Editor in Chief for the Journal of Veterinary Science. Professor Howarth is a Fellow of the American Gastroenterology Association and a member of the Royal College of Pathologists of Australasia. He is also an international assessor of Research Programs for the: (i) Ontario Ministry of Agriculture, Food and Rural Affairs; (ii) European Science Foundation; (iii) Netherlands Organization for Health Research and Development; and (iv) Singapore Health and Medical Research Council.