Pathways and co-expression network analysis of immune-related genes in short-term calorie restricted mice

Joint Event on 10^th International Conference on Genomics and Molecular Biology & 6^th International Conference on Integrative Biology

May 21-23, 2018 Barcelona, Spain

Nehir Ozdemir Ozgenturk, Zehra Omeroglu Ulu, Soner Dogan, Bilge Guvenc Tuna and Salih Ulu

Yildiz Technical University, Davutpasa Campus, Turkey
Yeditepe University, Turkey

Scientific Tracks Abstracts: J Mol Genet Med

Abstract :

RNA-seq technology was performed by using a comparative transcriptome analysis of the MMTV-TGF-�������± female mice thymus tissues that were fed ad libitum (AL), chronic calorie restriction (CCR) (85% of AL fed mice) and intermittent calorie restriction (ICR) (3 weeks AL fed, 1 week 40% of AL fed mice) from 10 weeks of age to 17 weeks of age or 18 weeks of age. The results of RNA-seq analysis, a total of 6091 significantly differentially expressed genes (DEGs) were identified. 2821, 2825 and 445 significantly DEGs were detected between AL-CCR, CCR-ICR and AL-ICR fed groups, respectively. These DEGs were classified according to cellular components, biological processes and molecular functions Gene Ontology (GO) main categories. 188 of 2821, 36 of 445, 176 of 2825 genes were identified to be involved in immune system process (GO:0002376) biological processes GO categories. KEGG pathway and the gene co-expression network analysis between AL-CCR, CCRICR and AL-ICR fed groups immune-related DEGs were done using String database. For network analysis, nodes and edges presented the interaction between immune-related DEGs.

Biography :

Nehir Ozdem�±r Ozgenturk completed her Graduation at Ege University; Master's degree in Plant Breeding department and; PhD in Department of Justus Liebieg University. In 2003, she worked at Cereal Research Center in Canada as a Post doc. Also she worked at Georgia Medical School for four months with Nato fellowship. She has scientific paper in various scientific journals, publications and presentations at international conferences.
Email:nehirozdemir@yahoo.com