Javier Rodr?guez, Signed Prieto, Catalina Correa, Leonardo Ram?rez, Astrid Rubiano, Dar?o Dom?nguez and Marcela Mej?a
Accepted Abstracts: J Cancer Sci Ther
Cervicovaginal cytology (CVC) evaluated by the current methodologies, such as the bethesda system, has low sensitivity and high false negative rates. One of the categories used for CVC diagnosis is ASCUS, which represents a nonspecific category under which intraepithelial lesions of low or high grade can be easily masked, evidentiating the importance of establishing an objective and reproducible method for determining the degree of differentiation of cervical squamous epithelial cells. In a previous work developed by Rodriguez et al., a new diagnostic method based on fractal geometry was developed to quantitatively differentiate normal cells from cells with low-grade lesions, based on the mathematical concept of intrinsic mathematical harmony (IMH) and variability of fractal dimension. In the present work, starting from fractal geometry and the concepts of IMH and cellular variability there were developed computational simulations of possible paths that could be taken by the squamous cervical cells from a normal stage to malignity. For this purpose, there were selected 10 normal cells, and 3 geometric variations of each one were made in the box counting space from normality to H-SIL, maintaining cellular IMH of each state, according to the developed diagnostic method. The simulations included relationships corresponding to the state called ASCUS, whose mathematical values can be normal or of L-SIL. The simulations obtained of possible paths from normality to ASCUS, L-SIL and H-SIL constitutes quantitative, objective and reproducible measures that evidence a fractal organization in the cellular architecture.