Oxytocin ımproves follicular reserve in a cisplatin-ınduced gonadotoxicity model in rats

4^th World Congress on Cancer Science & Therapy

October 20-22, 2014 DoubleTree by Hilton Hotel Chicago-North Shore Conference Center, USA

Oytun Erbas

Accepted Abstracts: J Cancer Sci Ther

Abstract :

Cis-Diamminedichloroplatinum (II)(cisplatin, CP) is an antitumor agent effective for treating various human cancers of the breast, brain, head and neck, stomach, lung, bladder, testis, and ovary. Its anti-tumor activity is attributed mainly to its ability to form platination products in the nuclear DNA. However, repetitive treatment with CP is associated with numerous side effects such as nephrotoxicity, neurotoxicity, and reproductive toxicity. In both animal and human studies, CP has been shown to cause ovarian injury, leading to ovarian dysfunction, changes in the estrous cycle, increased follicular apoptosis, and a reduction in the number of anti-Mullerian hormone-(AMH) secreting follicles. Oxytocin (OT), a nonapeptide produced in the paraventricular and supraoptic nuclei in the hypothalamus, is essentially associated with uterine contraction during parturition and milk ejection reflex during lactation. OT receptors (OTR) have been demonstrated not only in the uterine and myoepithelial tissues, but also in other tissues, including heart, thymus, kidney, pancreas, adipose tissue, and ovaries. Accumulating evidence suggests that OT exerts its cytoprotective effects via antioxidative, antiapoptotic, and anti-inflammatory pathways. Recently, we have shown its beneficial effects against sepsis-induced polyneuropathy, pentylenetetrazol-induced seizures, and rotenoneinduced Parkinson?s disease model in rats. Although several studies have demonstrated the protective role of OT in various types of tissue injury, there is still lack of data with regard to beneficial effects of this peptide in chemotherapy-induced ovarian gonadotoxicity. Therefore, we conducted the present study to explore whether OT has protective effects on follicle reserve in a CP-induced gonadotoxicity model in rats by evaluating histopathological alterations, plasma AMH levels, and ovary malondialdehyde (MDA) and glutathione (GSH) levels as markers of oxidative stress.

Biography :

Oytun Erbas has studied neuroprotective agents, oxytocin, metabolic syndrome and inflammation for 5 years, during which time he has authored 28 research papers. He especially investigates effects of chemotherapotic agent?s on over; chemopreventive and cytoprotective affects of oxytocin. Also, he has already shown oxytocin?s anti-inflammatuary (via decrease in levels of VEGF, TNF, MCP-1) and anti-convulsive nature. He is a member of the Federation of European Neuroscience Societies (FENS), International Brain Research Organization (IBRO) and Society for Neuroscience (SfN).