Oral ingestion of Spondias pinnata bark extract trim down severity of small intestinal mucositis in etoposide treated rats: Histological sequelae

Global Cancer Conference & Medicare Summit

September 15-17, 2014 Hyderabad International Convention Centre, India

Sudarshan Reddy C, Beena V Shetty and Gayathri M Rao

Posters: J Cancer Sci Ther

Abstract :

Chemotherapy-induced diarrhea (CID) is a common side effect of cancer treatment and can cause significant morbidity and mortality. Rat mucositis model was developed by injecting single dose of etoposide (i.p) and treated with S. pinnata bark extract (100 & 200 mg/kg body wt.) for next 72 hrs. Treatment efficacy was determined by changes in the intestinal morphology and biochemical parameters such as intestinal GSH, Sucrase, NO, MPO and Interleukin-6 (IL-6) after 72 hr, with and without intervention. There was a significant decrease in reduced glutathione, sucrase and IL-6 levels and a significant increase in NO and MPO activities in intestinal tissue after etoposide injection. However, in the post treatment groups (in both 100 & 200 mg), reduced glutathione, sucrase and IL-6 levels reverted back to that of normal. NO levels reverted to normal levels in response to 100 mg/kg body wt. of S. pinnata extract; however it remained high in the group treated with 200 mg/kg body wt. MPO levels showed least response to the intervention during the study. Histological studies showed a good response to S. pinnata bark extract intervention. The results suggest that S. pinnata bark extract has some potential to prevent the toxic effects of etoposide which expedites to mucositis.