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Novel tubulin binding agent, noscapine: A reverse story from clinical to preclinical
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Cancer Science & Therapy

ISSN: 1948-5956

Open Access

Novel tubulin binding agent, noscapine: A reverse story from clinical to preclinical


3rd World Congress on Cancer Science & Therapy

October 21-23, 2013 DoubleTree by Hilton Hotel San Francisco Airport, CA, USA

Ramesh Chandra

Accepted Abstracts: J Cancer Sci Ther

Abstract :

IGF axis factors and some binding proteins can cause occurrence and recurrence of breast cancer. On the other hand, the role of combination exercise training on these factors is not clear. Thus, the aim of this study was to clarify the effect of 15 weeks combination exercise training on IGF axis factors and some binding proteins in postmenopausal women with breast cancer. Twenty nine women with breast cancer (58.27?6.31 years) who received surgery, chemotherapy and radiation therapy with current hormone therapy were divided into two groups; intervention and control. Subjects of intervention group performed 15 weeks combination exercise training including walking (2 sessions per week) and resistance training (2 sessions per week that different from walking days). Data were analyzed by using ANCOVA (p≤0.05). The findings of present study demonstrated that 15 weeks combination exercise training had significant effect on IGF-1 levels (P=0.001), IGFB-3 levels (P=0.000) and IGF-1: IGFB-3 (P=0.000) in postmenopausal women with breast cancer. After 15 weeks, IGE-1 was reduced in intervention group up 9 percent and IGFB-3 was increased by 28 percent. On the other hand, exercise training had no significant effects on the IGFB-1 (P=0.652) in postmenopausal women with breast cancer. In conclusion, because the IGF axis factors and some binding proteins plays an important role in breast cancer and its recurrence, it seems that changes of these factors by combination exercise training can delay recurrence of breast cancer. Keywords: Combination exercise training, Breast cancer, Postmenopausal women, IGF-1, IGFBP-3, IGFBP-1.

Biography :

Reza Nuri has studied cancer and exercise training for 5+ years, during which time he has authored more than 15 peer-reviewed reports in this area. He has served on the editorial boards for the American Journal of Cancer Epidemiology and Prevention . He is the manager of research affairs of Kish International Campus, University of Tehran.

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