Novel biological pathways linking diabetes to colorectal cancer

Cancer Diagnostics Conference & Expo

June 13-15, 2016 Rome, Italy

Fatima A Mohsen

American University of Beirut, Lebanon

Posters & Accepted Abstracts: J Cancer Sci Ther

Abstract :

NADPH oxidase (NOX) enzymes are a family of heme-containing transmembrane proteins whose basic function is ROS production. In fact, diabetes has been shown to increase the generation of reactive oxygen species (ROS) and NOX-generated ROS have been linked to injury to various organs including the colon. Our main aim is to explore the mechanism by which diabetesinduced ROS accelerate colorectal tumor development and burden. Our results showed that treatment with high glucose and/or high insulin lead to a decrease in AMPK activity, increase in mTOR activity, ROS production and 8-oxodG adducts in CaCO2 and Ht-29 cells. High glucose and high insulin treatment also affected the cells� proliferation, migration and invasion properties. Our results also show that metformin and/or rapamycin treatments reverse those effects. Moreover, results from APC mice treated with metformin further exhibited the ability of this drug to attenuate NOXs expression caused by diabetes. These results reveal a novel molecular mechanism involved in colorectal cancer in diabetic patients and potential therapeutic methods for controlling CRC aggressiveness.

Biography :

Fatima A Mohsen is currently a PhD student at the University of Strasbourg, France in collaboration with the American University of Beirut, Lebanon. She has published a research paper as a result of her Master’s thesis project attained from the Lebanese University, Lebanon.

Email: fatima_mohsen91@hotmail.com