Molecular profiling of genetic alterations in prostate cancer patients from Northern India

7^th Global Summit on Cancer Therapy

October 05-07, 2015 Dubai, UAE

Bushra Ateeq

Indian Institute of Technology Kanpur, India

Posters-Accepted Abstracts: J Cancer Sci Ther

Abstract :

Molecular categorization of cancer based on specific genetic alterations and emergence of high-throughput technologies has led to recent advances in personalized medicine for the treatment of cancer. The seminal discovery of the gene rearrangement involving the androgen-regulated gene trans-membrane protease, serine 2 (TMPRSS2) with erythroblastosis virus E26 transformationspecific (ETS) transcription factor family (ERG, ETV1, ETV4 or ETV5) which is recurrent in ~50% of the prostate cancer (PCa) patients formed the basis for classification of the disease by distinct molecular subtypes. These molecular sub-types based on genetic aberrations including ETS, RAF gene-rearrangements, PTEN deletion and SPINK1 (serine peptidase inhibitor, Kazal type-1) overexpression showed clear prognostic and diagnostic value; however prevalence of these molecular alterations is largely unknown for the Indian PCa patient population. Here, we provided the first comprehensive report about the prevalence of the major causal aberrations in Indian PCa samples which include ERG, ETV1, ETV4 and RAF kinase genetic rearrangements, SPINK1 over-expression and PTEN deletions. Our findings suggest that ERG is highly recurrent (~49%) gene rearrangement among Indian PCa patients; furthermore, ETS gene rearrangement and SPINK1 over-expression patterns in Indian PCa cohort largely resembled those observed in Caucasian population but differed from Japanese and Chinese patients. The molecular sub-type data for Indian PCa patients could aid in early diagnosis and clinical decision-making for the pursuit of targeted therapy.

Biography :

Email: bushra@iitk.ac.in