Wei Lin Lo, Liang Cheng Chen, Chen Hsien Liang, Ming Wei Chen, Cheng Hui Chuang and Chih Hsien Chang
Institute of Nuclear Energy Research, Taiwan
Posters & Accepted Abstracts: J Cancer Sci Ther
The aim of this study was to investigate the in vivo distribution evaluation of intravenously administrated combination of Lipo- Dox and 188Re-liposome in breast solid tumor model by biodistribution and nanoSPECT/CT studies. Female BALB/c mice were subcutaneously inoculated with 4T1 cells. At 14 days after tumor inoculation, the tumor-bearing mice were intravenously injected via tail vein with pretreated Lipo-Dox (2.5 mg/kg) or pegylation liposome on day 1 and with the 11.1 MBq/100 ├?┬╝L of 188Re-liposome on day 4. Biodistribution and nanoSPECT/CT imaging were performed at 24 h after injection of 188Re-liposome. Biodistribution data of tumor sites were expressed as the percentage injected dose per gram of tissue (%ID/g). Each mouse was scanned for ~40 min by nanoSPECT/CT system. The obvious uptakes in nanoSPECT/CT images of tumor sites were observed at 24 h after injection of 188Reliposome in the pretreated Lipo-Dox group compared with that in pretreated pegylation liposome group. The tumor uptakes of the pretreated Lipo-Dox group and pegylation liposome group at 24 h after injection of 188Re-liposome were 5.8 %ID/g and 3.3 %ID/g in 4T1 solid tumor mice, respectively. In this study, mice with subcutaneous implantation of 4T1 murine breast cancer received the delivery of Lipo-Dox first, after a three-day interval, then with 188Re-liposome subsequently. The 188Re-liposome was more sufficiently delivered to tumor sites in mice with pretreated Lipo-Dox than mice with pretreated pegylation liposome. We are going to prove combination of Lipo-Dox and 188Re-liposome has the capability as potential therapeutic strategy for breast cancer in the future.
Liang Cheng Chen is the Associate Researcher of Isotope Application Division in Institute of Nuclear Energy Research. His major work is to investigate the preclinical animal study for drug efficacy, pharmacokinetics, dosimetry, molecular imaging and toxicology.
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