Identification of different miroRNA binding sites at 3’UTR region of bovine HSP90AA1 gene among different Indian breeds of cattle

2^nd Indo-Global Summit & Expo on Veterinary

October 26-28, 2015 Hyderabad, India

Rajib Deb1, Rafeeque R Alyethodi1, Basavraj Sajjanar2, Indra Singh3, T V Raja1, Umesh Singh1, Rani Alex1, Gyanendra Sengar1 and B Prakash1

1Central Institute for Research on Cattle, India 2National Institute for Abiotic Stress Management, India 3Indian Agricultural Statistical Research Institute, India

Posters-Accepted Abstracts: J Veterinar Sci Technol

Abstract :

3�UTR regions are the important targets for regulation of stressor genes in the mammalian system. A total of 28 mutations were identified in the 3�UTR region of bovine HSP90 gene among different indigenous and crossbred cattle. Results revealed that, crossbred cattle are more prone to natural mutational change compared to indigenous animals and the difference was statistically significant. Prediction of microRNA binding site revealed that, there are at least seven different micro RNAs which may interact at 3� un-translated region of bovine HSP90AA1 gene among different breed of cattle. Out of the seven microRNAs, miR8882 and miR3796 are the most commonly distributed among different cattle breeds while the miR9491 and miR-2277-5p were restricted to Gir and Ongole respectively. While miR8882 binding site were unanimous, miR3796 showed variation among the breeds.

Biography :

Email: drrajibdeb@gmail.com