Effect of honey bee venom on Candida albicans in comparison with ketoconazole amphotericin B

9^th International Conference on Clinical & Medical Case Reports

September 27-28, 2018 | Amsterdam, Netherlands

Shahin Gavanji , Jahangir Gavanji, Azizollah Bakhtari and Behrouz Larki

National herbal medicine center of Iran, Isfahan, Iran
Islamic Azad University, Iran
University of Isfahan, Iran
Isfahan University of Technology, Iran

Posters & Accepted Abstracts: J Clin Case Rep

Abstract :

Statement of the Problem: The Candida species are the most important factors of fungal infections in humans and animals. Due to resistance to anti-fungal drugs and side effect, honey bee venom is considered as an antimicrobial material. Methodology & Theoretical Orientation: At first, the venom was gathered by electric shocks and its antimicrobial properties were examined using disk diffusion method. MIC and MBC were calculated on Candida albicans compared with ketoconazole and amphotericin B in 24, 48 and 72 h. Then MIC, MFC and IZ between the venom and the drugs were calculated using ANOVA method and mean comparison was done using Tukey method. Findings: Results showed that different venom concentrations possess inhibitory effect on C. albicans and MIC and MFC were calculated 24 and 28 μg/mL respectively, comparison between the venom and two antifungal drugs also showed that the venom has low effect in given concentrations. A meaningful difference was observed between ketoconazole and amphotericin B in 0.05 levels. Conclusion & Significance: Results showed that honey bee venom possess antimicrobial properties on Candida albicans. So, more accurate toxicology examinations and derivation of compositions can help us to formulate new natural antibiotics.

Biography :

E-mail: shahin.gavanji12@gmail.com