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Comparative study of the cyto-genotoxicity effect of the leaves extracts of Annona muricata, Dacryodes edulis and Persea americana using Allium cepa L. assay and cell line culture
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Cancer Science & Therapy

ISSN: 1948-5956

Open Access

Comparative study of the cyto-genotoxicity effect of the leaves extracts of Annona muricata, Dacryodes edulis and Persea americana using Allium cepa L. assay and cell line culture


3rd World Congress on Cancer Science & Therapy

October 21-23, 2013 DoubleTree by Hilton Hotel San Francisco Airport, CA, USA

Nneka A. Akwu

Accepted Abstracts: J Cancer Sci Ther

Abstract :

The screening of three plant extracts ( Annona muricata, Dacryodes edulis and Persea americana ), which have been of significant interest to scientists; in the search for novel drugs for better effective treatment of a number of diseases. These plants? extracts and phytochemicals (a natural product from plants) with known medicinal properties can be of great significance in therapeutic treatments. There are limited number of literatures from Nigeria on the cytotoxic and genotoxic effects of the effective concentrations of the aquoeus extracts of the leaves of Annona muricata, Dacryodes edulis and Persea americana using Allium cepa L. assay and cell lines. There is a global common belief amongst medicinal plant users, that drugs derived from plants are always safe because they are ?natural". However, several evidences from scientific investigations suggest otherwise. Scientific investigations ( in vitro and in vivo assays) have revealed that many plants used as food or in traditional medicine have mutagenic and/or carcinogenic effects. The cytotoxicity and genotoxicity of some medicinal plants/herbs extracts, infusions, essential oils and fractions of many extracts have been widely evaluated using cytogenic approaches/assays. Vero cells are used for numerous research purposes, such as host cells for growing viruses which are subsequently used for the production of vaccines and also in cancer research to determine suitable drugs (synthetic- chemicals or natural-plants) for the selective destruction of different types of cancer.

Biography :

Nneka .A. Akwu is a graduate student of Cell and Molecular Biology and she has contributed to the writing of some journals and co-authored an international journal (her B.Sc. Project research). She is also a member of the Nigerian Society for Experimental Biology. Her area of research for her Doctorate is on Cancer Management using Novel Lead molecules from lower plants.

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