Sang Moo Lim
Korea Institute of Radiological and Medical Sciences, Republic of Korea
Posters & Accepted Abstracts: J Cancer Sci Ther
The aim of this study was to determine whether 18F-FDG PET-guided measurement of dynamic MRI parameters could predict disease-free survival (DFS) in patients with operable breast cancer. Seventy-eight patients with breast cancer were enrolled. All patients underwent preoperative parallel PET/MR. All patients were analyzed by diverse parameters (maximum SUV at 1 h [SUV1], retention index of SUVmax [RI], initial slope of the enhancement curve [IS], transfer constant [Ktrans], reflux constant [Kep], extravascular extracellular space volume fraction [Ve] and initial area under the curve [iAUC]). Dynamic MRI parameters were measured at the tumor region with SUV1. A relationship between covariates and DFS after operation was analyzed using Kaplan-Meier method and multivariate Cox proportional-hazard regression method. The median followup of 78 patients was 55 months, and 9 (11.5%) patients developed recurrence or metastasis. Among parameters, higher RI (p=0.0010), lower Ktrans (p=0.0046), and lower Ve (p=0.0035) were significantly associated with poorer DFS. In contrast, SUV1, IS, Kep, and iAUC were not. On multivariate analysis, RI (p=0.016; HR=5.20; CI 1.4-19.7), and Ktrans (p=0.035; HR=0.22; CI 0.054-0.89) were found as independent predictors of DFS. Patients with higher RI and lower Ktrans revealed a significantly higher recurrence rate (66.7%) than the rest of patients (6.9%, P<0.0001). 18F-FDG PET-guided measurement of dynamic MRI parameters could make improvement of patients care because tailored surveillance would be applied for high risk group.
Sang Moo Lim is the Director of the Department of Nuclear Medicine, Korea Institute of Radiological and Medical Sciences (KIRAMS), Seoul, Republic of Korea.
Email: nmbbh@hanmail.net
Cancer Science & Therapy received 3968 citations as per Google Scholar report
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