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Journal of Brain Research

Journal of Brain Research

ISSN: 2684-4583

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Top Journals Schizophrenia

Although praecox dementia or schizophrenia has been considered a single disease for more than a century, its definitions and limits have changed during this period and its etiology and pathophysiology remain elusive. Despite changing definitions, DSM-IV schizophrenia is reliably diagnosed, has fair validity, and provides useful clinical information. Therefore, the essence of the broad DSM-IV definition of schizophrenia is retained in DSM-5. The clinical manifestations are however extremely diverse, this heterogeneity being poorly explained by the clinical subtypes and the course specifiers of the DSM-IV. In addition, the boundaries of schizophrenia are delicately delimited from schizoaffective disorder and other diagnostic categories, and its particular emphasis on Schneiderian "first rank" symptoms seems out of place. The changes in the definition of schizophrenia in the DSM-5 are intended to fill these gaps and incorporate new information on the nature of the disorder accumulated over the past two decades. Specific changes in its definition include the elimination of classic subtypes, the addition of unique psychopathological dimensions, the clarification of specifiers of transverse and longitudinal paths, the elimination of special treatment for Schneiderian `` first-order symptoms '' , better delineation of schizophrenia from schizoaffective disorder, and clarification of the relationship of schizophrenia to catatonia. These changes are expected to improve the diagnosis and characterization of people with schizophrenia, facilitate measurement-based treatment, and simultaneously provide a more useful platform for research that will elucidate its nature and allow for more precise delineation of "schizophrenia" in the future.

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