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Tissuechips Applications | Open Access Journals
Journal of Tissue Science and Engineering

Journal of Tissue Science and Engineering

ISSN: 2157-7552

Open Access
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Tissuechips Applications

Tissue chips merge techniques from the computer industry with those from bioengineering by combining miniature models of living organ tissues onto a transparent microchip. Ranging in size from a coin to a house key, the chips are lined with living cells and contain features designed to replicate the complex biological function of a specific organ. The goal is to develop human tissue chips that simulate the structure and function of human organs, such the lung, heart, liver, and kidneys. Scientists could then use these tissue chips to test drug candidates and predict their safety before the next step, human drug studies. This approach is expected be more rapid and cost effective than those currently available.The high rate of failure during drug development is well-known, however recent advances in tissue engineering and microfabrication have contributed to the development of microphysiological systems (MPS), or ‘organs-on-chips’ that recapitulate the function of human organs. These ‘tissue chips’ could be utilized for drug screening and safety testing to potentially transform the early stages of the drug development process. They can also be used to model disease states, providing new tools for the understanding of disease mechanisms and pathologies, and assessing effectiveness of new therapies. In the future, they could be used to test new treatments and therapeutics in populations – via clinical trials-on-chips – and individuals, paving the way for precision medicine. Here we will discuss the wide-ranging and promising future of tissue chips, as well as challenges facing their development.

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Citations: 807

Journal of Tissue Science and Engineering received 807 citations as per Google Scholar report

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