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Systemic Sclerosis Review Articles | Open Access Journals
Journal of Health & Medical Informatics

Journal of Health & Medical Informatics

ISSN: 2157-7420

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Systemic Sclerosis Review Articles

Systemic sclerosis (SSc) is a chronic disease of multisystem connective tissue with protean clinical manifestations. Recent advances in the understanding of pathogenic mechanisms have led to the development of targeted vasomodulatory drugs which play a central role in the treatment of various dermatological manifestations. Comprehensive literature search was conducted using Medline, Embase and Cochrane Library to examine recent concepts regarding the pathogenesis and evidence-based treatment of prominent dermatologic manifestations. The concept of shared genetic risk factors for the development of autoimmune diseases is seen in SSc. It is divided into fibroproliferative and inflammatory groups based on molecular profiling at the genome level. Genetic, infectious and environmental factors play a key role; vascular lesions, fibrosis and immune activation are the main pathogenic factors. Vitamin D deficiency has been documented in the SSc and is correlated with the severity of the skin involvement. Cutaneous sclerosis, Raynaud's phenomenon (RP) with digital vasculopathies, pigmentation, calcinosis and leg ulcers affect the patient's quality of life.

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Citations: 2700

Journal of Health & Medical Informatics received 2700 citations as per Google Scholar report

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