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Rhabdoid Carcinoma Open Access Journals | Open Access Journals
Cancer Science & Therapy

Cancer Science & Therapy

ISSN: 1948-5956

Open Access

Rhabdoid Carcinoma Open Access Journals

Primary osteosarcoma with rhabdoid features is a rare malignant bone neoplasm, previously not described, with histological features of both primary osteosarcoma and those of rhabdoid cells. Osteosarcoma is a mesenchymal neoplasm which represents 15% of all primary bone tumors [1, 2]. Primary osteosarcoma is a very aggressive tumor, with a bimodal distribution; its incidence peaks in the second decade of life and increases again later in life in the elderly with Paget's disease [3]. The lesions are generally metaphyseal and most often observed in areas of high bone turnover: the distal femur, the proximal tibia and the proximal humerus [1, 4]. The World Health Organization has divided osteosarcoma into eight classifications based on anatomical location and histology: conventional, secondary, telangiectatic, small cell, low grade, parosteal, periosteal and high grade surface types [5]. In addition, these can be subdivided according to the predominant matrix produced: osteoblastic, chondroblastic or fibroblastic [1, 4]. The determining histological characteristic for the diagnosis of all variants of osteosarcoma is the presence of mesenchymal cells producing osteoids [3]. These cells are spindle-shaped to polyhedral, with pleomorphic nuclei and occasional mitotic figures [1]. The osteoid seen in histopathology has a distinct appearance: eosinophilic, dense and amorphous [4].

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