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Relapsing-Remitting Multiple Sclerosis Innovations | Open Access Journals
Journal of Oncology Medicine & Practice

Journal of Oncology Medicine & Practice

ISSN: 2576-3857

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Relapsing-Remitting Multiple Sclerosis Innovations

Relapsing-remitting multiple sclerosis (MS-RR). Multiple sclerosis (MS) is a chronic inflammatory, demyelinating and neurodegenerative disease. As acetylcholine (ACh) is known to participate in the inflammatory response, we investigated the possible relationship between pro-inflammatory cytokines and acetylcholine levels in patients with relapsing-remitting multiple sclerosis (RR-MS) . The ACh and pro-inflammatory cytokines IL1-β and IL-17 levels were measured in both cerebrospinal fluid (CSF) and serum of 22 relapsed RR-MS patients and in 17 control subjects affected by d other non-neurological diseases (OND). We observed higher levels of pro-inflammatory cytokines such as IL-1β and IL-17 in the CSF and serum of RR-MS patients compared to control subjects. In addition, ACh levels were lower in the CSF and serum of RR-MS patients compared to the levels of control subjects. Although the relationship between high levels of inflammatory cytokines and low levels of ACh should be investigated in more detail in the future, our data suggest that IL-1β and the cytokines induced by it, such as IL -17 and Ache, could be involved in the pathogenesis of MS.

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Citations: 142

Journal of Oncology Medicine & Practice received 142 citations as per Google Scholar report

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