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Progressive Multifocal Leukoencephalopathy Journals | Open Access Journals
Immunochemistry & Immunopathology

Immunochemistry & Immunopathology

ISSN: 2469-9756

Open Access

Progressive Multifocal Leukoencephalopathy Journals

Progressive multifocal leukoencephalopathy (PML) may be a rare, myelin-damaging malady of the central system (CNS) in an exceedingly setting of immunological disorder that's superimposed by coinciding reaction diseases like induration and AIDS or synchronic administration of immune modulatory antibody medication like natalizumab. The motive agent may be a Polyomavirus referred to as John professional dancer (JC) virus (JCV) that affects oligodendrocytes and astrocytes leading to focal, intensive and progressive degenerative disorder across the brain. The pathological process of JCV latent and active infection is nevertheless to be totally understood despite important medical analysis. To date, no therapeutic intervention has been terribly effective in addressing the health implications of PML. during this article, we have a tendency to review the present data on the life cycle of JCV, pathological process of PML, highlight necessary tools within the designation, potential targets for management and therapeutic intervention of PML.

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