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Osmopressor Response | Open Access Journals

Journal of Hypertension: Open Access

ISSN: 2167-1095

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Osmopressor Response

Consumption of water elicits profound pressive responses in patients with impaired baroreflex function and in denominated sinoaortic mice. Healthy people experience more subtle changes in heart rate and blood pressure when drinking water. The water-induced pressure response appears to be mediated by sympathetic activation of the nervous system in the spine. In fact, water consumption increases energy expenditure at rest in subjects of normal weight and obese. The stimulus that triggers the response is hypoosmolarity rather than water temperature or gastrointestinal stretch. Studies in mice suggest that this osmopressor response may involve potential transient receptors for vanniloid 4 (Trpv4) receptors. However, the population of (nerve) cells serving as peripheral osmosensors and the exact transduction mechanisms are still unknown. The osmopressor response can be exploited in the treatment of postural and postprandial hypotension in patients with severe autonomic insufficiency. In addition, the osmopressor response acutely improves orthostatic tolerance in healthy subjects and in patients with neural mediated syncope. The phenomenon should be recognized as a major confounding factor in cardiovascular and metabolic studies.

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Citations: 614

Journal of Hypertension: Open Access received 614 citations as per Google Scholar report

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