Mycobacterium tuberculosis (Mtb), the etiological agent of human tuberculosis (TB), has been rife for thousands of years. Tuberculosis remains a major public health problem in our time, causing more than 4,400 deaths worldwide every day and killing more people than HIV. After inhaling aerosols contaminated with Mtb, the primary tuberculosis infection begins in the terminal pulmonary respiratory tract, where Mtb is absorbed by alveolar macrophages. Although macrophages are known as professional pathogen killers, Mtb has adopted remarkable strategies for bypassing host defenses, creating the right conditions for survival and proliferation. Within macrophages, Mtb initially resides inside phagosomes, where its survival depends mainly on its ability to take control of the phagosomal process, by inhibiting the biogenesis and acidification processes of phagolysosomes and by progressive access to the cytosol. Bacterial access to the cytosolic space is crucial for specific immune responses and cell death programs, both of which are necessary for the replication and dissemination of Mtb.
Editorial: Medical Microbiology & Diagnosis
Editorial: Medical Microbiology & Diagnosis
Research Article: Medical Microbiology & Diagnosis
Research Article: Medical Microbiology & Diagnosis
Research Article: Medical Microbiology & Diagnosis
Research Article: Medical Microbiology & Diagnosis
Case Report: Medical Microbiology & Diagnosis
Case Report: Medical Microbiology & Diagnosis
Editorial: Medical Microbiology & Diagnosis
Editorial: Medical Microbiology & Diagnosis
Posters & Accepted Abstracts: Medical Microbiology & Diagnosis
Posters & Accepted Abstracts: Medical Microbiology & Diagnosis
Posters & Accepted Abstracts: Medical Microbiology & Diagnosis
Posters & Accepted Abstracts: Medical Microbiology & Diagnosis
Posters & Accepted Abstracts: Medical Microbiology & Diagnosis
Posters & Accepted Abstracts: Medical Microbiology & Diagnosis
Keynote: Medical Microbiology & Diagnosis
Keynote: Medical Microbiology & Diagnosis
Posters & Accepted Abstracts: Medical Microbiology & Diagnosis
Posters & Accepted Abstracts: Medical Microbiology & Diagnosis
Medical Microbiology & Diagnosis received 14 citations as per Google Scholar report
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