Summary Historical, clinical, economic, and technological developments have driven a shift in clinical practice from predominantly 6-hour-long hemodialysis treatments to much shorter treatment times that are prevalent today. Patients, physicians, and providers had considered shortening dialysis treatments as a way to decrease the general burden imposed by this necessary life-saving therapy. However, shorter dialysis is not a panacea and may engender trade-offs in terms of patient morbidity and mortality. We examine the literature with the advantage of hindsight and in light of recent studies that have improved understanding of the complex relationship between dialysis dose and outcome. We affect the role of dialysis frequency relative to treatment time. We conclude with the suggestion that a replacement treatment paradigm should consider a minimum adequate dialysis treatment time of 4 hours for the bulk of patients, with anything shorter becoming the exception rather than the rule.Barriers to shortening TT were overcome one by one through innovative refinements to dialyzer membrane design that enhanced diffusive permeability, improved engineering of dialysis delivery equipment, and made modifications to dialysate composition. The major objective was to extend dialytic capacity for solute clearance (primarily measured in terms of urea removal) so on maintain an equivalent total clearance over less time. The hollow fiber dialyzer design allowed for a compact, more efficient use of area to maximise diffusion (6,7). Membrane materials evolved from basic cellulose into cuprophane then semisynthetic and fully synthetic fibers that allowed for enhanced diffusive clearance also as greater convective solute and fluid flux (8). The enhanced capacity for fluid removal necessitated precise control of ultrafiltration rate, spurring the event of blood pumps and volumetric ultrafiltration
Posters & Accepted Abstracts: Cancer Science & Therapy
Posters & Accepted Abstracts: Cancer Science & Therapy
Scientific Tracks Abstracts: Cancer Science & Therapy
Scientific Tracks Abstracts: Cancer Science & Therapy
Scientific Tracks Abstracts: Alternative & Integrative Medicine
Scientific Tracks Abstracts: Alternative & Integrative Medicine
Keynote: Journal of Forensic Research
Keynote: Journal of Forensic Research
ScientificTracks: Cancer Science & Therapy
ScientificTracks: Cancer Science & Therapy
Hepatology and Pancreatic Science received 34 citations as per Google Scholar report
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