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G-Quadruplexes | Open Access Journals
Molecular and Genetic Medicine

Molecular and Genetic Medicine

ISSN: 1747-0862

Open Access

G-Quadruplexes

G-quadruplexes are noncanonical macromolecule structures formed from stacked guanine tetrads. They are frequently used as building blocks and functional elements in fields like synthetic biology and also thought to play widespread biological roles. In molecular biology, G-quadruplex secondary structures (G4) are formed in nucleic acids by sequences that are rich in guanine They are helical in shape and contain guanine tetrads that can form from one or four strands. The unimolecular forms often occur naturally near the ends of the chromosomes, better known as the telomeric regions, and in transcriptional regulatory regions of multiple genes, both in microbes and across vertebrates including oncogenes in humans.

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Citations: 3919

Molecular and Genetic Medicine received 3919 citations as per Google Scholar report

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