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Endothelium Derived Hyperpolarizing Factor | Open Access Journals
Cardiovascular Diseases & Diagnosis

Cardiovascular Diseases & Diagnosis

ISSN: 2329-9517

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Endothelium Derived Hyperpolarizing Factor

The endothelium maintains vascular homeostasis by the release of active vasodilators. Although nitric oxide (NO) is recognized as the main factor in the arteries, there is increased evidence of the role of another endothelium-derived vasodilator known as endothelium-derived hyperpolarizing factor (EDHF) have accumulated in recent years. Experiments show that when NO and prostacyclin (vasodilators) are inhibited, there is yet another factor causing dilation of the vessels. important characteristic of the "healthy" endothelium. Since the contribution of EDHF is most important at the level of small arteries, changes in the action of EDHF are of critical importance for the regulation of organ blood flow, peripheral vascular resistance and blood pressure, and especially when NO production is compromised. In addition, depending on the type of altered cardiovascular disorder, EDHF responses can contribute to or compensate for endothelial abnormalities associated with the pathogenesis of certain diseases. It is widely accepted that EDHF plays an important role in vasotone, especially in micro-vessels. Its effect varies depending on the size of the ship.

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