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Endometrial And Ovarian Cancers | Open Access Journals
Journal of Clinical Case Reports

Journal of Clinical Case Reports

ISSN: 2165-7920

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Endometrial And Ovarian Cancers

Synchronous endometrial and ovarian carcinomas occur in approximately 5% of endometrial carcinomas and 10-20% of ovarian carcinomas, respectively (1,2). The distinction between independent primary tumors and metastases from one site to another (endometrium to the ovary or ovary to the endometrium) can be complicated but it is clinically significant. Historically, the criteria for this distinction have evolved and were mainly based on morphological characteristics (3,4). However, a great advantage has been expected from auxiliary methods (in particular molecular analyzes) which are now becoming, with methodological development, more complex and also more available. Surprisingly, the results of recent molecular studies have shown that most SEOs share clonal origin regardless of their clinical pathological characteristics (5-7). The advantage of molecular analysis regarding the differential diagnosis between independent primary tumors and metastatic disease is, from this point of view, debatable. However, in a recent study, the authors suggested that molecular profiling could be beneficial in this context (8). However, this suggestion was based on the molecular profiling of a single SEO. In our study, we focused on a complete clinical-pathological and molecular study of 22 cases of SEO.

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