Anti-HBc IgG and IgM antibodies are the body's first response to infection with the hepatitis B virus (HBV). These antibodies are directed against a part of HBV called "core". Anti-HBc IgG and IgM appear shortly after symptoms and the appearance of the measurable viral surface antigen (HBsAg). IgM arrives first and is then replaced by IgG. Total anti-HBc (IgG plus IgM) is interpreted in the light of clinical factors and the results of other markers of hepatitis B, in particular HBsAg and anti-HBs.
A total anti-HBc negative result may indicate the absence of a recent or previous HBV infection (HBsAg negative and anti-HBs). However, a developing infection cannot be ruled out. The combination of negative anti-HBc and total HBsAg results, but positive anti-HBs results indicates that an individual has been vaccinated against hepatitis B. In combination with positive HBsAg / negative HBsAg, a total anti-HBc test negative may indicate an individual in the acute phase of the disease or reactivation of the virus in a chronic carrier.
Research Article: Medical Microbiology & Diagnosis
Research Article: Medical Microbiology & Diagnosis
Editor Note: Medical Microbiology & Diagnosis
Editor Note: Medical Microbiology & Diagnosis
Opinion Article: Medical Microbiology & Diagnosis
Opinion Article: Medical Microbiology & Diagnosis
Review Article: Medical Microbiology & Diagnosis
Review Article: Medical Microbiology & Diagnosis
Letter to Editor: Medical Microbiology & Diagnosis
Letter to Editor: Medical Microbiology & Diagnosis
Survey report: Medical Microbiology & Diagnosis
Survey report: Medical Microbiology & Diagnosis
Research Article: Medical Microbiology & Diagnosis
Research Article: Medical Microbiology & Diagnosis
Editorial: Medical Microbiology & Diagnosis
Editorial: Medical Microbiology & Diagnosis
Posters & Accepted Abstracts: Medical Microbiology & Diagnosis
Posters & Accepted Abstracts: Medical Microbiology & Diagnosis
Posters & Accepted Abstracts: Medical Microbiology & Diagnosis
Posters & Accepted Abstracts: Medical Microbiology & Diagnosis
Posters & Accepted Abstracts: Medical Microbiology & Diagnosis
Posters & Accepted Abstracts: Medical Microbiology & Diagnosis
Posters & Accepted Abstracts: Medical Microbiology & Diagnosis
Posters & Accepted Abstracts: Medical Microbiology & Diagnosis
Scientific Tracks Abstracts: Medical Microbiology & Diagnosis
Scientific Tracks Abstracts: Medical Microbiology & Diagnosis
Scientific Tracks Abstracts: Medical Microbiology & Diagnosis
Scientific Tracks Abstracts: Medical Microbiology & Diagnosis
Posters & Accepted Abstracts: Medical Microbiology & Diagnosis
Posters & Accepted Abstracts: Medical Microbiology & Diagnosis
Posters & Accepted Abstracts: Medical Microbiology & Diagnosis
Posters & Accepted Abstracts: Medical Microbiology & Diagnosis
Medical Microbiology & Diagnosis received 14 citations as per Google Scholar report
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