Molecular and Genetic Medicine

Trends and Advancements in Immunomics

The advances in immunomics is the establishment of functional genomics due to the development of DNA microarray is one of the most active and successful scientific innovation.

Immunomics studies the response and regulation process of the immune system on pathogens, which deals with all immune-related molecules, together with their targets and functions. Immunomics includes the techniques of genomics, proteomics, and bioinformatics. On the basis of genomics and proteomics research, immunomics makes full use of bioinformatics, biochip technologies, structural biology, high-throughput screening, and systems biology methods to study the immune system and immune responses so as to discover susceptibility-related genes and immune-related molecules. Immune system being a highly complex system, traditional research methods is largely limited. While immunomics may become a powerful new approach, immunomics is currently applied primarily in vaccine development, target identification, and disease diagnosis as follows.

Immunome leverages the information stored in memory B cells to guide the discovery of first-in-class antibody therapeutics directed at potentially novel targets: In immunology, a memory B cell (MBC) is a type of B lymphocyte that forms part of the adaptive immune system. These cells develop within germinal centers of the secondary lymphoid organs. Memory B cells circulate in the blood stream in a quiescent state, sometimes for decades.

Tumor immunology, immunomics and targeted immunotherapy for central nervous system malignancies: Tumor immunology refers to the relationship between immune function and tumor cells, which is crucial for our understanding of the mechanisms of both tumor rejection and tumor progression. The immunological mechanisms involved in cancer growth are highly complex, including tissue-resident and blood-derived cells

The Immunome as Diagnostic:

For diagnostic purposes, the expansion of antigen-specific B or T cell clones acts as a signal amplifier, indicating a response to a specific antigen or antigens in the form of an increased frequency of cells expressing antigen-specific antibody and/or TR genes in the immunome.

Immunity is mainly categorized into two types namely

• Active Immunity
• Passive Immunity

Active Immunity results when exposure to a disease organism triggers the immune system to produce antibodies to that disease. Active immunity can be acquired through natural immunity or vaccine-induced immunity.

Passive immunity is provided when a person is given antibodies to a disease rather than producing them through his or her own immune system.

This journal publishes all the articles related to the scope of special issue Trends and Advancements in Immunomics.

Note: This special issue releasing scheduled probably by June 2022.