A rare autosomal recessive white matter condition known as megalencephalic leukoencephalopathy with subcortical cysts. During the first year of life, both patients experience macrocephaly and demonstrate a gradual loss of motor functions, including ataxia and spasticity.
Microarray study of gene expression profiling Treatment with drugs for microarray analysis: Prior to therapy, HFLS-RA cells were seeded in 75 cm2 culture flasks for 24 hours. MTX IC50 concentrations were used to treat the cells.
The use of biomarkers in basic and clinical research as well as in clinical practice has become so commonplace that their presence as primary endpoints in clinical trials is now accepted almost without question. In the case of specific biomarkers that have been well characterized and repeatedly shown to correctly predict relevant clinical outcomes across a variety of treatments and populations, this use is entirely justified and appropriate.
The primary recognition has traditionally been on biomarkers of sickness indeed, it has been proposed that the preliminary utility of biomarkers might also date to the practice of culturing infections to improve treatment charges when antibiotics were first delivered throughout global battle II.