International Journal of Neurorehabilitation

Department of Medicine, New York Presbyterian Hospital--Weill/Cornell Medical School, New York, USA

Publications

• Mini Review   
  Injury to the Spinal Cord is helped by a Reactive Oxygen Species-Responsive Hydrogel that Contains Bone Marrow-Derived Stem Cells
  Author(s): William Faulkner*
  
  The disabling and overwhelming condition known as spinal cord injury (SCI) is accompanied by intricate inflammation-related pathological processes like the release of excessive reactive oxygen species (ROS) into the extracellular microenvironment and widespread apoptosis of neuron, glial, and oligodendroctyl cells by infiltrating inflammatory immune cells. For the purpose of encapsulating bone marrow derived mesenchymal stem cells (BMSCs), a thioketal-containing and ROS-scavenging hydrogel was made in this study. This hydrogel promoted neurogenesis and axon regeneration by scavenging the overproduced ROS and re-building a regenerative microenvironment. By reducing the production of endogenous reactive oxygen species (ROS), attenuating ROS-mediated oxidative damage, and downregulating inflammatory cytokines like interleukin-1 beta (IL-1), interleukin-6 (IL-6) an.. Read More»
  DOI: 10.37421/2376-0281.2022.9.495

  Abstract HTML PDF