Department of Medical Laboratory Science, Nnamdi Azikiwe University, Awka, Nigeria
Case Report
Identification of Single-nucleotide Polymorphisms (SNPs) of Enterococcus faecal Isolated from HIV Seropositive Nigerian Patients with CD4+ Cells of<200 Cells/μl: A Possible Vaccine Target
Author(s): Ehiaghe Friday Alfred*, Ehiaghe Imuetinya Joy, Rebecca Chinyelu Chukwuanukwu, Onah Ejike Christian, Ihim Augustine Chinedu, Ochiabuto Mary-Theodora Ogochukwu, Unaeze Chukwuebuka Bright, Obi Chioma Maureen, Ukibe Rose Nkiruka, Osakue Omoyemen Nosahkare, Onyenekwe Charlse Chinedum, Meludu Chukwuemeka Samuel, Manafa Patrick Onochie and Emeje Paul Isaac
Enterococci have gained significance as the cause of nosocomial infections. They occur as food contaminants and have also been linked to dental diseases. Currently, infective endocarditis (IE) caused by Enterococcus faecalis represents 10% of all IE and is marked by its difficult management and the frequency of relapses. Although the precise reasons for that remain to be elucidated, the evolution of the culprit strain based on single nucleotide polymorphism (SNP) could be, at least in part, involved. The cross sectional study randomly selected 40 consented (25 male and 15 female) HIV seropositive patients and body mass index of 16.7 ± 1.0 (Kg/m2 ) with CD4+ cells<200 cells/µl. Urine and feces samples were collected used for testing. Chrom agar was used for bacterial isolation. DNA isolations from the 24-hour growth cultures of possible Enterococcu.. Read More»
DOI:
10.37421/1747-0862.2023.17.592
Molecular and Genetic Medicine received 3571 citations as per Google Scholar report
