Journal of Brain Research

ISSN: 2684-4583

Open Access

Tianjiao Zhao

Department of Plastic Surgery, The First Affiliated Hospital of Sun Yat-Sen University, No. 58 Zhongshan Road 2, Guangzhou 510080, China

  • Research Article   
    WGCNA Analysis of Gene Expression Difference between Afferent and Efferent Nerves in Mice during Development
    Author(s): Yi Zhang*, Koon Hei Winson Lui, Guanggeng Wu, Tianjiao Zhao, Di Wen, Peiwen Bai, Yangbin Xu and Xiangxia Liu

    The efferent (motor) and afferent (sensory) nerves may appear physically similar in structure, however with closer inspection, numerous differences could be observed in terms of cellular composition, extracellular matrix or structure. To investigate the reason for the differences, study was conducted on the gene expression of the afferent and efferent nerve fibers during the stage of growth and development. Analysis was conducted on the afferent and efferent nerve chip data of the mice (data coded GSE113820) from the GEO database. This set of data contained information derived from the nervous tissue of C57BL/6 mice. To reduce statistical bias, Weighted Gene Co-Expression Network Analysis (WGCNA) was used for the analysis. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis were performed in specific modules obtained after WGCNA analy.. Read More»
    DOI: 10.37421/2684-4583.2023.6.184

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