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Molecular and Genetic Medicine

ISSN: 1747-0862

Open Access

Tan Z

Department of Pathophysiology, Anhui Medical University, Hefei, Anhui, P.R. China

Publications
  • Short Communication   
    IKZF2 Driving Self-Renewal and Inhibiting Myeloid Differentiation Through Chromatin Accessibility
    Author(s): Wu M, Tan Z, Ma M, Tao S, Liu X* and Zheng H*

    Control of myeloid differentiation and leukemia stem cell (LSC) self-renewal involves genetic and epigenetic regulators and mechanisms. Genetic regulation in leukemia has been highlighted as a novel way for maintaining the LSC program. Translocations of histone methyltransferases, such as the mixed-lineage leukemia (MLL) genes including Hoxa9, Myc, and Ikzf2, give rise to one of the most aggressive subtypes of acute myeloid leukemia (AML). Uncontrolled expansion of immature myeloid cells coupled with leukemia stem cell self-renewal and a block in differentiation are some of the characteristic traits of AML... Read More»

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Google Scholar citation report
Citations: 3919

Molecular and Genetic Medicine received 3919 citations as per Google Scholar report

Molecular and Genetic Medicine peer review process verified at publons

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