Molecular and Genetic Medicine

Department of Biochemistry, Pt. B.D. Sharma Post Graduate Institute of Medical Sciences, Rohtak-124001, Haryana, India

Publications

• Research Article   
  Polymorphism of Glutathione S‑Transferase M1 and T1 Genes and Susceptibility to Childhood Asthma: A Study from North India
  Author(s): Srivastava DSL*, Mittal K, Jindal P and Kumar A
  
  Objectives: Glutathione S-transferases (GSTs) enzymes play an important role in the xenobiotic biotransformation of endogenous or exogenous toxicants and thought to protect the airways from oxidative stress, inflammation, and genotoxicity. Polymorphisms in the GST genes may lead to an increased imbalance in antioxidant systems and may influence the pathogenesis of asthma. We examined the association of the GST gene polymorphism to ascertain whether high-risk genotypes of GSTM1/GSTT1 could influence the susceptibility to childhood asthma in the N orth Indian population. Methods: The study constituted of 100 childhood asthmatic cases and 180 age-matched controls. The GSTT1 and GSTM1 null genotypes were identified by multiplex PCR in peripheral blood DNA samples. Statistical analysis was done by using SP.. Read More»
  DOI: 10.37421/1747-0862.2021.15.477

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